상세정보
학술대회
Estimation of Beta-amyloid Quantity Using Photo-Sensitive Field Effect Transistor Integrated with a Selectively Transmissible Optical Filter
- 발행일
- 201105
- 출처
- International Conference on Computers, Networks, Systems and Industrial Engineering (CNSI) 2011, pp.277-280
- 협약과제
- 11SF1300, 생체진단 가능 시각/미각 수용체 기반 센싱 기술 개발, 송기봉
- 초록
- The intra/extracellular beta-amyloid (A棺) of neuron has been known as the most representative hallmark of Alzheimer's disease (AD). Recently, the clinical diagnosis of AD has been significantly issued with early detection of A棺. For further accurate quantification of A棺 compared to current techniques, we suggest a new technical concept that enables the evaluation of as small as a few femtomolar A棺 peptide by using photo-sensitive field-effect transistor (p-FET) coated with selectively transmissible optical filter for a particular range of wavelengths of excitation beam. The photo-current generated by p-FET with arsenic trisulfide (As2S3) filter is as much apparent as about 76 nA for a small amount of A棺-conjugated fluorescent particles. This result indicates that even with slightly small amount of A棺 peptides the As2S3 coated p-FET is applicable to recognizing optically tenuous fluorescence. © 2011 IEEE.
- KSP 제안 키워드
- Alzheimer's Disease(AD), Beta-amyloid, Clinical diagnosis, Early Detection, Field-effect transistors(FETs), Optical filters, Photo-current, Photo-sensitive, fluorescent particles