BROWSE
Detail
Conference Paper
Estimation of Beta-amyloid Quantity Using Photo-Sensitive Field Effect Transistor Integrated with a Selectively Transmissible Optical Filter
Cited 0 time in 
Share 
Share
- Issue Date
- 2011-05
- Citation
- International Conference on Computers, Networks, Systems and Industrial Engineering (CNSI) 2011, pp.277-280
- Language
- English
- Type
- Conference Paper
- Abstract
- The intra/extracellular beta-amyloid (A棺) of neuron has been known as the most representative hallmark of Alzheimer's disease (AD). Recently, the clinical diagnosis of AD has been significantly issued with early detection of A棺. For further accurate quantification of A棺 compared to current techniques, we suggest a new technical concept that enables the evaluation of as small as a few femtomolar A棺 peptide by using photo-sensitive field-effect transistor (p-FET) coated with selectively transmissible optical filter for a particular range of wavelengths of excitation beam. The photo-current generated by p-FET with arsenic trisulfide (As2S3) filter is as much apparent as about 76 nA for a small amount of A棺-conjugated fluorescent particles. This result indicates that even with slightly small amount of A棺 peptides the As2S3 coated p-FET is applicable to recognizing optically tenuous fluorescence. © 2011 IEEE.
- KSP Keywords
- Alzheimer's Disease(AD), Beta-amyloid, Clinical diagnosis, Early detection, Field Effect Transistor(FET), Fluorescent particles, Optical filters, Photo-current, Photo-sensitive